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KMID : 0613820130230121445
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Journal of Life Science
2013 Volume.23 No. 12 p.1445 ~ p.1453
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Down-regulation of Tyrosinase, MITF, TRP-1, and TRP-2 Expressions by Juniperus rigida Sieb. in Murine B16F10 Melanoma
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Lee Soo-Yeon
Jun Hye-Ji
Lee In-Chul
Lee Jin-Young
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Abstract
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Human skin is constantly exposed to ultraviolet (UV) radiation, polluted air, and chemical products. UV rays, in particular, will affect the skin in a variety of ways, including causing wrinkles, fine lines, rough skin, and xeroderma, thereby resulting in skin aging. This study aimed to investigate the whitening effects of Juniperus rigida Sieb., which is a cedar tree that is found throughout the world. The whitening efficacy that was measured by tyrosinase inhibition revealed 49.4% efficacy in water extract and 80.0% efficacy in ethanol extract. Among the B16F10 black cells, the effect of the ethanol extract was higher than the effect of the water extract in the restrain creation of melanin pigment, tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), and tyrosinase related protein-2 (TRP-2). Thus, the results of these studies demonstrated that the ethanol extract had greater efficacy than the water extract and Juniperus rigida Sieb. Ethanol extracts could be utilized as materials for functional cosmetics, such as whitening products.
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KEYWORD
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Juniperus rigida Sieb., microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase related protein-1 (TRP-1), tyrosinase related protein-2 (TRP-2)
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